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KMID : 1040120170030020131
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Evidence and Values in Healthcare
2017 Volume.3 No. 2 p.131 ~ p.137
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Liver Fibrosis test using Mac-2 Binding Protein Glycosylation isomer : a systematic review
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Lim Ji-Ae
Kim So-Young
Choi Won-Jung
Kim Seok-Hyun
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Abstract
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Objectives: The aim of this research was to assess the safety and effectiveness for diagnosing liver fibrosis in patients with chronic liver disease by measuring the Mac-2 binding protein glycosylation isomer (M2BPGi) through chemiluminecence enzyme immunoassay.
Methods: The literature review for liver fibrosis test using M2BPGi was done using 8 Korea databases, Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library. These databases were systematically searched from 1946 until September 2016. A total of 14 articles were included in the final assessment by two reviewers.
Results: The test are conducted outside the body using blood samples. Accordingly, there is no risk to the subjects from performing the test itself following the procedure. According to the diagnostic evaluation studies, the specificity and AUC of M2BPGi (2 articles) was higher than the comparison tests, and the correlation coefficient with the Fibroscan® (2 articles) was 0.6 or more. According to the accuracy of prognosis prediction results (8 articles), the higher cut-off value in M2BPGi indicated poor prognosis.
Conclusion: In conclusion, liver fibrosis test using M2BPGi was evaluated to be a safe and effective technique as a screening test preceding the liver biopsy for diagnosing liver fibrosis in patients with chronic liver disease.
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KEYWORD
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Liver fibrosis, Mac-2 binding protein glycosylation isomer (M2BPGi), Safety, Effectiveness
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